Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4939710 | 0.95 | ADORA2A (0.45) | ADORA2ATMIGD3ADORA1DHFRHTT | |
| SCHEMBL4945533 | 0.92 | ADORA2A (0.45) | ADORA2AADORA1DHFRHTT | |
| SCHEMBL4946031 | 0.89 | ADORA2A (0.51) | ADORA2AUSP2ADORA1DHFRHTT | |
| SCHEMBL4946126 | 0.82 | ALDH1A1 (0.44) | ADORA2AADORA1DHFRHTT | |
| SCHEMBL4946832 | 0.81 | CNR2 (0.52) | ADORA2AUSP2ADORA1DHFRHTT | |
| SCHEMBL4947050 | 0.81 | AURKA (0.51) | ADORA2AUSP2ADORA1DHFRHTT | |
| SCHEMBL4946014 | 0.80 | ADORA2A (0.47) | ADORA2AUSP2ADORA1DHFRHTT | |
| SCHEMBL4943901 | 0.76 | TSHR (0.42) | USP2DHFRHTT | |
| SCHEMBL4947297 | 0.73 | ADORA3 (0.46) | ADORA2AADORA1DHFRHTT | |
| SCHEMBL4942378 | 0.72 | DHFR (0.48) | ADORA2AADORA1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697356-B1 | PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINES AS PDE 2 INHIBITORS | PFIZER PROD INC (US) | 2008-02-27 | — | — | EP | disclosed |
| US-20070135457-A1 | Pyrido[2,3-d]pyrimidine-2,4-diamines as pde2 inhibitors | PFIZER INC. | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135457-A1 | Pyrido[2,3-d]pyrimidine-2,4-diamines as pde2 inhibitors | PDE12, PDE2A, PDE3A | ADORA2A 60/4885USP2 1533/4885TMIGD3 4166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.