Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.49 |
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL27698497 | 0.91 | CYP2C9 (0.49) | ABCG2ALDH1A1LMNATSHRCYP2C9 | |
| Isopropyl Alcohol SCHEMBL4955206 | 0.91 | NPY5R (0.50) | ABCG2ALDH1A1LMNATSHRCYP2C9 | |
| SCHEMBL4203388 | 0.88 | TSHR (0.67) | ABCG2ALDH1A1LMNATSHRCYP2C9 | |
| SCHEMBL4456862 | 0.86 | ALDH1A1 (0.60) | ABCG2ALDH1A1LMNATSHRLPAR3 | |
| SCHEMBL30043252 | 0.86 | TSHR (0.64) | ABCG2ALDH1A1LMNATSHRCYP2C9 | |
| SCHEMBL6273333 | 0.86 | TSHR (0.64) | ABCG2ALDH1A1LMNATSHRCYP2C9 | |
| SCHEMBL9356592 | 0.84 | ALDH1A1 (0.67) | ALDH1A1LMNATSHRCYP2C9CYP2C19 | |
| SCHEMBL9158141 | 0.84 | ALDH1A1 (0.67) | ALDH1A1LMNATSHRCYP2C9CYP2C19 | |
| SCHEMBL11453175 | 0.81 | LMNA (0.57) | ABCG2ALDH1A1LMNATSHRCYP2C9 | |
| SCHEMBL9214229 | 0.81 | ALDH1A1 (0.73) | ALDH1A1LMNATSHRCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273908-B2 | Process for the preparation of estrone and/or estradiol-derivatives | MSD OSS B.V. (NL) | 2012-09-25 | — | — | US | claimed |
| CN-101010332-B | Process for the preparation of estrone and/or estradiol derivatives | ORGANON NV | 2012-01-18 | — | — | CN | claimed |
| CN-102229635-A | Process for the preparation of estrone and/or estradiol-derivates | AKZO NOBEL NV | 2011-11-02 | — | — | CN | claimed |
| EP-1794175-B1 | PROCESS FOR THE PREPARATION OF ESTRONE AND/OR ESTRADIOL-DERIVATES | ORGANON NV (NL) | 2008-08-13 | — | — | EP | claimed |
| US-20070299268-A1 | Process for the Preparation of Estrone and/or Estradiol-Derivates | N.V. ORGANON (NL) | 2007-12-27 | — | — | US | claimed |
| CN-101010332-A | Process for the preparation of estrone and/or estradiol derivatives | ORGANON NV (NL) | 2007-08-01 | — | — | CN | claimed |
| EP-1794175-A1 | PROCESS FOR THE PREPARATION OF ESTRONE AND/OR ESTRADIOL-DERIVATES | N.V. Organon (NL) | 2007-06-13 | — | — | EP | claimed |
| WO-2006021554-A1 | PROCESS FOR THE PREPARATION OF ESTRONE AND/OR ESTRADIOL-DERIVATES | N.V. ORGANON (NL) | 2006-03-02 | — | — | WO | claimed |
| CN-102229635-B | Process for the preparation of estrone and/or estradiol-derivates | AKZO NOBEL NV | 2015-01-28 | — | — | CN | disclosed |
| US-8273908-B2 | Process for the preparation of estrone and/or estradiol-derivatives | MSD OSS B.V. (NL) | 2012-09-25 | — | — | US | disclosed |
| CN-101010332-B | Process for the preparation of estrone and/or estradiol derivatives | ORGANON NV | 2012-01-18 | — | — | CN | disclosed |
| CN-102229635-A | Process for the preparation of estrone and/or estradiol-derivates | AKZO NOBEL NV | 2011-11-02 | — | — | CN | disclosed |
| EP-1794175-B1 | PROCESS FOR THE PREPARATION OF ESTRONE AND/OR ESTRADIOL-DERIVATES | ORGANON NV (NL) | 2008-08-13 | — | — | EP | disclosed |
| US-20070299268-A1 | Process for the Preparation of Estrone and/or Estradiol-Derivates | N.V. ORGANON (NL) | 2007-12-27 | — | — | US | disclosed |
| CN-101010332-A | Process for the preparation of estrone and/or estradiol derivatives | ORGANON NV (NL) | 2007-08-01 | — | — | CN | disclosed |
| EP-1794175-A1 | PROCESS FOR THE PREPARATION OF ESTRONE AND/OR ESTRADIOL-DERIVATES | N.V. Organon (NL) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006021554-A1 | PROCESS FOR THE PREPARATION OF ESTRONE AND/OR ESTRADIOL-DERIVATES | N.V. ORGANON (NL) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299268-A1 | Process for the Preparation of Estrone and/or Estradiol-Derivates | CYP19A1, HSD17B11, HSD17B7 | ABCG2 1246/4885ALDH1A1 241/4885LMNA 4154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.