Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL891297 | 0.83 | CA1 (0.39) | ALDH1A1TDP1KDM4EHPGDMAPT | |
| SCHEMBL27952201 | 0.70 | TTR (0.32) | SMN1; SMN2TDP1HPGDTSHR | |
| SCHEMBL7784690 | 0.66 | TDP1 (0.43) | HTTSMN1; SMN2ALDH1A1ALOX15TP53 | |
| SCHEMBL17102731 | 0.66 | SMN1; SMN2 (0.39) | HTTSMN1; SMN2ALDH1A1ALOX15TP53 | |
| SCHEMBL4388377 | 0.66 | GUCY1A1 (0.42) | HTTSMN1; SMN2ALDH1A1ALOX15TP53 | |
| SCHEMBL2840115 | 0.64 | TDP1 (0.54) | SMN1; SMN2ALDH1A1ALOX15TP53CYP3A4 | |
| SCHEMBL1341419 | 0.63 | S100B (0.50) | SMN1; SMN2ALDH1A1ALOX15TP53CYP3A4 | |
| SCHEMBL11755583 | 0.63 | HTT (0.58) | HTTSMN1; SMN2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL1339989 | 0.63 | TDP1 (0.43) | SMN1; SMN2ALDH1A1ALOX15TP53CYP3A4 | |
| SCHEMBL19088749 | 0.62 | TDP1 (0.52) | SMN1; SMN2ALDH1A1ALOX15TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986622-A2 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007095340-A2 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2007-08-23 | — | — | WO | disclosed |