Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949129 | 0.70 | CCNA2 (0.39) | — | |
| SCHEMBL8751588 | 0.65 | TSHR (0.52) | LMNATSHRKDM4EGAAHPGD | |
| SCHEMBL30707094 | 0.64 | POLB (0.34) | L3MBTL1MAPTPOLB | |
| SCHEMBL27320089 | 0.62 | TSHR (0.47) | LMNATSHRKDM4EGAAHPGD | |
| SCHEMBL11740247 | 0.61 | TSHR (0.46) | LMNATSHRKDM4EGAAHPGD | |
| SCHEMBL6700583 | 0.60 | TSHR (0.46) | LMNATSHRKDM4EGAAHPGD | |
| SCHEMBL11040263 | 0.60 | TSHR (0.48) | LMNATSHRKDM4EGAAHPGD | |
| SCHEMBL8706315 | 0.60 | TSHR (0.47) | LMNATSHRKDM4EGAAHPGD | |
| SCHEMBL7824240 | 0.58 | LMNA (0.55) | LMNATSHRKDM4EGAAHPGD | |
| SCHEMBL4968161 | 0.58 | GABRA1 (0.46) | LMNATSHRKDM4EGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885725-A1 | TRICYCLIC AZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006108488-A1 | TRICYCLIC AZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-10-19 | — | — | WO | disclosed |