Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | FDPS | P14324 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4953206 | 0.95 | SIGMAR1 (0.61) | SIGMAR1FDPS | |
| SCHEMBL4344215 | 0.89 | TAAR1 (0.54) | SIGMAR1NPC1RAB9AGAAFDPS | |
| SCHEMBL13469007 | 0.86 | BCHE (0.67) | SIGMAR1NPC1RAB9AEPHX2 | |
| SCHEMBL158734 | 0.85 | SIGMAR1 (0.67) | SIGMAR1L3MBTL1NPC1RAB9AGAA | |
| SCHEMBL5106492 | 0.84 | MAOB (0.46) | SIGMAR1L3MBTL1FDPS | |
| SCHEMBL5099654 | 0.84 | CA2 (0.48) | SIGMAR1L3MBTL1KDM4ECYP2C19 | |
| SCHEMBL10766680 | 0.84 | SIGMAR1 (0.66) | SIGMAR1L3MBTL1FDPS | |
| SCHEMBL9776078 | 0.83 | LMNA (0.47) | SIGMAR1L3MBTL1NPC1RAB9AGAA | |
| SCHEMBL9776115 | 0.83 | LMNA (0.47) | SIGMAR1L3MBTL1NPC1RAB9AGAA | |
| SCHEMBL5106212 | 0.83 | HDAC3 (0.46) | SIGMAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008026075-A2 | TREATMENT OF INTRACELLULAR BACTERIAL INFECTIONS WITH A PROTEIN KINASE INHIBITOR OR AN AS160 POLYPEPTIDE ACTIVATOR | VERENIGING HET NEDERLANDS KANKER INSTITUUT (NL) | 2008-03-06 | — | — | WO | disclosed |
| US-6420385-B1 | INFLAMMATORY, PAIN AND DIABETES DISEASES, | AMGEN INC. | 2002-07-16 | — | — | US | disclosed |
| US-5672615-A | MATRIX-DEGRADING METALLOPROTEINASE INHIBITORS | NOVARTIS CORPORATION (US) | 1997-09-30 | — | — | US | disclosed |
| US-4639468-A | Derivatives of glycinamide, their preparation and their use | CONTINENTAL PHARMA INC. (BE) | 1987-01-27 | — | — | US | disclosed |