Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.36 |
| ▸ | TUBB | P07437 | 2/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4948740 | 0.83 | TTR (0.37) | MAPTALDH1A1LMNAPOLBTP53 | |
| SCHEMBL3590737 | 0.75 | POLB (0.40) | MAPTALDH1A1LMNASMN1; SMN2TUBB4A | |
| SCHEMBL1448474 | 0.72 | ABCB1 (0.37) | MAPTALDH1A1LMNASMN1; SMN2TUBB4A | |
| SCHEMBL4948554 | 0.70 | EIF4E (0.38) | MAPTLMNASMN1; SMN2POLBABCB1 | |
| SCHEMBL7371404 | 0.66 | ERN1 (0.51) | MAPTALDH1A1LMNASMN1; SMN2TUBB4A | |
| SCHEMBL3582569 | 0.66 | POLB (0.39) | MAPTALDH1A1LMNASMN1; SMN2TUBB4A | |
| SCHEMBL4948557 | 0.64 | TTR (0.51) | MAPTALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL3581240 | 0.64 | MAPT (0.40) | MAPTALDH1A1LMNASMN1; SMN2TUBB4A | |
| SCHEMBL3591585 | 0.64 | POLB (0.42) | MAPTALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL4949287 | 0.62 | POLB (0.41) | MAPTALDH1A1LMNASMN1; SMN2TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907382-A1 | NITROCATECHOL DERIVATIVES AS COMT INHIBITORS | Portela & C.A. S.A (PT) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007013830-A1 | NITROCATECHOL DERIVATIVES AS COMT INHIBITORS | PORTELA & CA. S.A. (PT) | 2007-02-01 | — | — | WO | disclosed |