Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.72 |
| ▸ | CA2 | P00918 | 3/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.68 |
| ▸ | CA9 | Q16790 | 1/20 | 0.68 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.60 |
| ▸ | CA1 | P00915 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28506881 | 0.90 | HTR6 (0.66) | HTR6CA2CA12CA9FFAR4 | |
| Trifluoroacetic Acid SCHEMBL15648070 | 0.89 | FFAR4 (0.59) | HTR6CA2CA12CA9FFAR4 | |
| SCHEMBL1024534 | 0.89 | ALDH1A1 (0.65) | HTR6CA2FFAR4CA1KMT2A | |
| SCHEMBL13265931 | 0.85 | HTR6 (0.53) | HTR6CA2CA12CA9FFAR4 | |
| SCHEMBL27888184 | 0.85 | HTR6 (0.68) | HTR6CA2CA12CA9FFAR4 | |
| SCHEMBL28271812 | 0.84 | HTR6 (1.00) | HTR6CA2CA9CA1KMT2A | |
| SCHEMBL28271833 | 0.83 | HTR6 (0.54) | HTR6CA2CA12CA9FFAR4 | |
| SCHEMBL28270344 | 0.83 | HTR6 (0.64) | HTR6CA2CA12CA9FFAR4 | |
| SCHEMBL28270327 | 0.82 | GUSB (0.56) | HTR6CA2CA12CA9FFAR4 | |
| SCHEMBL2243550 | 0.82 | CA2 (0.68) | CA2CA12CA9FFAR4CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109081793-B | Sulfonamide urease inhibitor and preparation method and application thereof | 吉首大学 | 2021-03-30 | — | — | CN | disclosed |
| CN-109081793-A | Sulfonamides urease inhibitor and its preparation method and purposes | 吉首大学 | 2018-12-25 | — | — | CN | disclosed |
| CN-107810189-A | Method for preparing nitrogen mustard derivatives | 肿瘤多肽股份公司 | 2018-03-16 | — | — | CN | disclosed |
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7074789-B2 | Kinase inhibitors | AMGEN INC. (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1218360-A1 | TRIAZINE KINASE INHIBITORS | Amgen Inc., (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001025220-A1 | TRIAZINE KINASE INHIBITORS | AMGEN INC. (US) | 2001-04-12 | — | — | WO | disclosed |