Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.56 |
| ▸ | CSF1R | P07333 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949063 | 0.90 | CSF1R (0.56) | PDE4BCSF1RLMNALRRK2 | |
| SCHEMBL4948799 | 0.90 | PDE4B (0.56) | PDE4BCSF1RLRRK2 | |
| SCHEMBL4948930 | 0.88 | CSF1R (0.53) | PDE4BCSF1RLMNALRRK2 | |
| SCHEMBL4952544 | 0.87 | PDE4B (0.70) | PDE4BCSF1RLRRK2 | |
| SCHEMBL1275872 | 0.85 | PDE4B (0.61) | PDE4BCSF1RLRRK2 | |
| SCHEMBL4951386 | 0.85 | PDE4B (0.74) | PDE4BCSF1R | |
| SCHEMBL4948633 | 0.83 | PDE4B (0.67) | PDE4BCSF1RLRRK2 | |
| SCHEMBL1276135 | 0.82 | PDE4B (0.75) | PDE4BCSF1RLRRK2 | |
| SCHEMBL2479835 | 0.81 | PDE4B (0.60) | PDE4BCSF1RLRRK2 | |
| SCHEMBL4950307 | 0.80 | PDE4B (0.47) | PDE4BCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |