Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 10/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4944374 | 0.91 | PDE4B (0.67) | CSF1RPDE4BJAK2JAK1TYK2 | |
| SCHEMBL1276139 | 0.85 | PDE4B (0.65) | CSF1RPDE4B | |
| SCHEMBL4949063 | 0.83 | CSF1R (0.56) | CSF1RPDE4B | |
| SCHEMBL4951564 | 0.81 | CSF1R (0.53) | CSF1RPDE4B | |
| SCHEMBL4949101 | 0.80 | PDE4B (0.68) | CSF1RPDE4B | |
| SCHEMBL4952737 | 0.79 | PDE4B (0.61) | CSF1RPDE4B | |
| SCHEMBL4952739 | 0.78 | PDE4B (0.48) | CSF1RPDE4B | |
| SCHEMBL4951405 | 0.78 | PDE4B (0.63) | CSF1RPDE4B | |
| SCHEMBL4952577 | 0.77 | PDE4B (0.74) | CSF1RPDE4B | |
| SCHEMBL4951019 | 0.77 | PDE4B (0.46) | CSF1RPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |