Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | GUSB | P08236 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2439422 | 0.83 | KDM4E (0.42) | KDM4ELMNATP53TDP1ALOX15 | |
| SCHEMBL4312001 | 0.82 | ABCG2 (0.42) | KDM4ELMNATP53TDP1ALOX15 | |
| SCHEMBL8227408 | 0.79 | CTSS (0.40) | KDM4ELMNATP53TDP1ALOX15 | |
| SCHEMBL4948354 | 0.76 | LMNA (0.49) | KDM4ELMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL8233506 | 0.68 | ADORA3 (0.44) | KDM4ELMNATDP1ALOX15SMN1; SMN2 | |
| SCHEMBL17716994 | 0.66 | LMNA (0.70) | KDM4ELMNATP53TDP1ALOX15 | |
| SCHEMBL2437475 | 0.66 | LMNA (0.42) | KDM4ELMNATP53TDP1ALOX15 | |
| SCHEMBL2439096 | 0.66 | KMT2A (0.45) | KDM4ELMNATP53TDP1ALOX15 | |
| SCHEMBL17716972 | 0.64 | KDM4E (0.71) | KDM4ELMNATP53TDP1ALOX15 | |
| SCHEMBL4309573 | 0.62 | LMNA (0.41) | KDM4ELMNATP53TDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976511-A2 | FLUORINATED ARYLAMIDE DERIVATIVES | Merck & Co., Inc. (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007087129-A2 | FLUORINATED ARYLAMIDE DERIVATIVES | MERCK & CO., INC. (US) | 2007-08-02 | — | — | WO | disclosed |