Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 3/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3603870 | 0.94 | PARP1 (0.41) | PARP1TSHRHTR2AHTR2CMEN1 | |
| SCHEMBL1057902 | 0.86 | PARP1 (0.52) | PARP1HTR2AHTR2CADRA2AADRA2B | |
| SCHEMBL23258708 | 0.80 | PARP1 (0.40) | PARP1HTR2AHTR2CMEN1KMT2A | |
| SCHEMBL14147026 | 0.77 | PARP1 (0.40) | PARP1TSHRMEN1KMT2ABCL2L1 | |
| SCHEMBL28507933 | 0.77 | BCL2L1 (0.52) | PARP1TSHRHTR2AMEN1KMT2A | |
| SCHEMBL2061156 | 0.77 | PARP1 (0.43) | PARP1TSHRMEN1KMT2ABCL2L1 | |
| SCHEMBL1835217 | 0.76 | PARP1 (0.39) | PARP1TSHRBCL2L1BADHTR1A | |
| SCHEMBL38654029 | 0.72 | ITGB2 (0.41) | ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL4362031 | 0.72 | HTR7 (0.41) | PARP1TSHRHTR1A | |
| SCHEMBL7322972 | 0.72 | PARP1 (0.58) | PARP1MEN1KMT2ABCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9579641-B2 | Aryl phosphines with fused ring ortho-alkoxy substitution | DOW GLOBAL TECHNOLOGIES LLC (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160184811-A1 | ARYL PHOSPHINES WITH FUSED RING ORTHO-ALKOXY SUBSTITUTION | DOW GLOBAL TECHNOLOGIES LLC (US) | 2016-06-30 | — | — | US | disclosed |
| WO-2015077194-A1 | INHIBITORS OF LYSINE METHYL TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-28 | — | — | WO | disclosed |
| US-20080194539-A1 | Phenyl Diazepane Carboxamides and Annelated Phenyl Piperazine Carboxamides Containing Oxygen and Used as Dopamine D3 Antagonists | SCHWARZ PHARMA AG (DE) | 2008-08-14 | — | — | US | disclosed |
| EP-1761524-B1 | PHENYL DIAZEPANE CARBOXAMIDES AND ANNELATED PHENYL PIPERAZINE CARBOXAMIDES CONTAINING OXYGEN AND USED AS DOPAMINE D3 ANTAGONISTS | SANOL ARZNEI SCHWARZ GMBH (DE) | 2007-11-21 | — | — | EP | disclosed |
| EP-1761524-A1 | PHENYL DIAZEPANE CARBOXAMIDES AND ANNELATED PHENYL PIPERAZINE CARBOXAMIDES CONTAINING OXYGEN AND USED AS DOPAMINE D3 ANTAGONISTS | SCHWARZ PHARMA AG (DE) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006072430-A1 | PHENYL DIAZEPANE CARBOXAMIDES AND ANNELATED PHENYL PIPERAZINE CARBOXAMIDES CONTAINING OXYGEN AND USED AS DOPAMINE D3 ANTAGONISTS | SCHWARZ PHARMA AG (DE) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160184811-A1 | ARYL PHOSPHINES WITH FUSED RING ORTHO-ALKOXY SUBSTITUTION | ALK, PHOSPHO1, MPL | PARP1 3058/4885TSHR 1688/4885HTR2A 1487/4885 |
| US-20080194539-A1 | Phenyl Diazepane Carboxamides and Annelated Phenyl Piperazine Carboxamides Containing Oxygen and Used as Dopamine D3 Antagonists | DRD3, DRD2, DRD1 | PARP1 928/4885TSHR 666/4885HTR2A 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.