SCHEMBL4950976

SCHEMBL4950976

O=C1CC=C(C(F)(F)F)N=C1c1cccc(-c2cc(O)c(O)c([N+](=O)[O-])c2)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 1/20 0.42
CRHR2 Q13324 1/20 0.42
TTR P02766 3/20 0.37
MAOA P21397 5/20 0.37
MAOB P27338 5/20 0.37
GPR35 Q9HC97 3/20 0.35
MAPT P10636 3/20 0.35
KDM4E B2RXH2 2/20 0.35
MEN1 O00255 2/20 0.35
ALDH1A1 P00352 2/20 0.35
CYP2C9 P11712 2/20 0.35
HPGD P15428 2/20 0.35
MAPK1 P28482 2/20 0.35
RECQL P46063 2/20 0.35
PMP22 Q01453 2/20 0.35
KMT2A Q03164 2/20 0.35
HIF1A Q16665 2/20 0.35
HSD17B10 Q99714 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
GMNN O75496 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4947992 0.88 ALOX5 (0.41) CRHBPCRHR2TTRMAPTMEN1
SCHEMBL3590761 0.73 CRHBP (0.49) CRHBPCRHR2TTRGPR35MAPT
SCHEMBL3587085 0.72 CRHBP (0.48) CRHBPCRHR2TTRGPR35MAPT
SCHEMBL3581492 0.72 CRHBP (0.48) CRHBPCRHR2TTRGPR35MAPT
SCHEMBL3591823 0.71 CRHBP (0.47) CRHBPCRHR2TTRGPR35MAPT
SCHEMBL3581623 0.69 CRHBP (0.45) CRHBPCRHR2TTRGPR35MAPT
SCHEMBL1446958 0.69 CRHBP (0.47) CRHBPCRHR2TTRGPR35MAPT
SCHEMBL1446727 0.69 CRHBP (0.47) CRHBPCRHR2TTRGPR35MAPT
SCHEMBL1447584 0.69 CRHBP (0.47) CRHBPCRHR2TTRGPR35MAPT
SCHEMBL1447074 0.67 CRHBP (0.45) CRHBPCRHR2TTRGPR35MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1907382-A1 NITROCATECHOL DERIVATIVES AS COMT INHIBITORS Portela & C.A. S.A (PT) 2008-04-09 EP disclosed
WO-2007013830-A1 NITROCATECHOL DERIVATIVES AS COMT INHIBITORS PORTELA & CA. S.A. (PT) 2007-02-01 WO disclosed