⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184048 | 0.86 | STAT3 (0.31) | — | |
| SCHEMBL4953870 | 0.86 | STAT3 (0.31) | — | |
| SCHEMBL845845 | 0.83 | — | — | |
| SCHEMBL6438566 | 0.75 | MGAM (0.30) | — | |
| SCHEMBL17884354 | 0.74 | OGA (0.33) | — | |
| SCHEMBL9843982 | 0.73 | STAT3 (0.30) | — | |
| SCHEMBL8191896 | 0.73 | ALDH1A1 (0.33) | — | |
| SCHEMBL6436811 | 0.71 | — | — | |
| SCHEMBL15445060 | 0.71 | STAT3 (0.33) | — | |
| SCHEMBL8045018 | 0.71 | OGA (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101502531-A | 3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of hepatites virus infections | PHARMASSET INC (US) | 2009-08-12 | — | — | CN | disclosed |
| EP-1284741-B1 | 3'-OR 2'-HYDROXYMETHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS | PHARMASSET INC (US) | 2008-11-19 | — | — | EP | disclosed |
| EP-1964569-A2 | 3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of viral infections | Pharmasset, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| US-7094770-B2 | 3′-or 2′-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections | PHARMASSET, LTD. (BB) | 2006-08-22 | — | — | US | disclosed |
| EP-1284741-A2 | 3'-OR 2'-HYDROXYMETHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES FOR TREATMENT OF HEPATITIS VIRUS INFECTIONS | Pharmasset, Ltd. (BB) | 2003-02-26 | — | — | EP | disclosed |
| US-20020055483-A1 | 3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of hepatites virus infections | PHARMASSET, INC. | 2002-05-09 | — | — | US | disclosed |
| WO-2001079246-A2 | 3'-OR 2'-HYDROXYMETHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES FOR TREATMENT OF HEPATITIS VIRUS INFECTIONS | PHARMASSET, LTD. (BB) | 2001-10-25 | — | — | WO | disclosed |