Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4401406 | 0.97 | GSK3B (0.37) | GSK3BCYP3A4CHRNA7TNKSTNKS2 | |
| SCHEMBL4386384 | 0.90 | CYP2C9 (0.38) | GSK3BCHRNA7SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4383569 | 0.84 | GSK3B (0.37) | GSK3BCYP3A4SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4379543 | 0.82 | CYP1A2 (0.38) | GSK3BCYP3A4CYP2D6 | |
| SCHEMBL4384596 | 0.81 | GSK3B (0.37) | GSK3BCYP3A4TNKSTNKS2CYP2D6 | |
| SCHEMBL2066076 | 0.81 | GSK3B (0.47) | GSK3BCYP3A4CYP2D6 | |
| SCHEMBL4377805 | 0.81 | ALDH1A1 (0.45) | GSK3BCHRNA7SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL2065745 | 0.80 | KDM4E (0.40) | GSK3BCYP3A4SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4377879 | 0.80 | MEN1 (0.45) | GSK3BCYP3A4CYP2D6 | |
| SCHEMBL4380168 | 0.79 | GSK3B (0.38) | GSK3BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |