Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 17/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380168 | 0.97 | GSK3B (0.38) | CYP1A2GSK3BUSP30CYP2D6CSNK1A1 | |
| SCHEMBL4391283 | 0.89 | CYP2C9 (0.39) | CYP1A2MEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2065745 | 0.88 | KDM4E (0.40) | CYP1A2CYP3A4GSK3BCYP2D6CAMKK2 | |
| SCHEMBL4377879 | 0.87 | MEN1 (0.45) | CYP1A2MEN1CYP3A4KMT2AGSK3B | |
| SCHEMBL2066088 | 0.85 | GSK3B (0.40) | CYP1A2CYP3A4GSK3BCYP2D6 | |
| SCHEMBL2065434 | 0.84 | GSK3B (0.45) | CYP1A2MEN1KMT2AGSK3BCYP2D6 | |
| SCHEMBL4385660 | 0.84 | RAB9A (0.48) | MEN1KMT2AGSK3BCYP2D6 | |
| SCHEMBL4378646 | 0.84 | MEN1 (0.46) | CYP1A2MEN1CYP3A4KMT2AGSK3B | |
| SCHEMBL2065082 | 0.83 | GSK3B (0.39) | CYP1A2GSK3BCYP2D6 | |
| SCHEMBL4383569 | 0.83 | GSK3B (0.37) | CYP3A4GSK3BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | claimed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | claimed |
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | disclosed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |