Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379543 | 0.97 | CYP1A2 (0.38) | GSK3BUSP30CYP2D6CYP1A2CSNK1A1 | |
| SCHEMBL2066088 | 0.87 | GSK3B (0.40) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL4378646 | 0.87 | MEN1 (0.46) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL4385660 | 0.87 | RAB9A (0.48) | GSK3BCYP2D6 | |
| SCHEMBL4391283 | 0.86 | CYP2C9 (0.39) | GSK3BCYP1A2CSNK1A1GSK3A | |
| SCHEMBL2065745 | 0.85 | KDM4E (0.40) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL4377879 | 0.84 | MEN1 (0.45) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL2065359 | 0.84 | GSK3B (0.46) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL2066076 | 0.84 | GSK3B (0.47) | GSK3BCYP2D6CYP1A2 | |
| SCHEMBL2065105 | 0.84 | GSK3B (0.44) | GSK3BCYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | claimed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |