Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.46 |
| ▸ | PREP | P48147 | 1/20 | 0.46 |
| ▸ | FAP | Q12884 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752669 | 0.83 | TSHR (0.57) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL1280773 | 0.82 | TSHR (0.56) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL6047270 | 0.81 | PSMB1 (0.56) | TSHRPSMB5PSMB1POLBNPSR1 | |
| SCHEMBL11964126 | 0.80 | TSHR (0.54) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL11827268 | 0.80 | TSHR (0.54) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL2825177 | 0.79 | PSMB5 (0.55) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL10813398 | 0.78 | ESR1 (0.42) | TSHRCYP2C19KMT2AHPGDL3MBTL1 | |
| SCHEMBL9752613 | 0.78 | TSHR (0.51) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL10656937 | 0.77 | TSHR (0.59) | TSHRPSMB5PSMB1POLBKMT2A | |
| SCHEMBL12530443 | 0.77 | TSHR (0.51) | TSHRPSMB5PSMB1PREPFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375079-B2 | Previns as specific inhibitors and therapeutic agents for botulinum toxin B and tetanus neurotoxins | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2008-05-20 | — | — | US | claimed |
| US-20060247176-A1 | Previns as specific inhibitors and therapeutic agents for Botulinum toxin B and Tetanus neurotoxins | ARMY, GOVERNMENT OF THE UNITED STATES DEPARTMENT OF THE ARMY (US) | 2006-11-02 | — | — | US | claimed |
| US-20050113304-A1 | Previns as specific inhibitors and therapeutic agents for Botulinum toxin B and Tetanus neurotoxins | ARMY, GOVERNMENT OF THE UNITED STATES DEPARTMENT OF THE ARMY (US) | 2005-05-26 | — | — | US | claimed |
| US-6573244-B1 | Compound in purified and isolated form or salts, esters, amides, and acyl forms thereof, selected from peptides having specified amino acid sequences | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2003-06-03 | — | — | US | claimed |
| WO-2022081983-A1 | INHIBITING HUMAN INTEGRIN A4B7 | MORPHIC THERAPEUTIC, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-3994874-A | ANTIBACTERIAL | RICHARDSON-MERRELL INC. (US) | 1976-11-30 | — | — | US | disclosed |
| US-3956287-A | BACTERICIDES | RICHARDSON-MERRELL INC. (US) | 1976-05-11 | — | — | US | disclosed |