Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.45 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | FAP | Q12884 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10842925 | 0.86 | TSHR (0.50) | TSHRPOLBNPSR1PSMB5PSMB1 | |
| SCHEMBL9752669 | 0.81 | TSHR (0.57) | TSHRPOLBNPSR1PSMB5PSMB1 | |
| SCHEMBL1280773 | 0.79 | TSHR (0.56) | TSHRPOLBNPSR1PSMB5PSMB1 | |
| SCHEMBL11964126 | 0.78 | TSHR (0.54) | TSHRPOLBNPSR1PSMB5PSMB1 | |
| SCHEMBL11827268 | 0.78 | TSHR (0.54) | TSHRPOLBNPSR1PSMB5PSMB1 | |
| SCHEMBL4956341 | 0.78 | TSHR (0.54) | TSHRPOLBNPSR1PSMB5PSMB1 | |
| SCHEMBL6108133 | 0.76 | — | — | |
| SCHEMBL8600961 | 0.76 | — | — | |
| SCHEMBL9752595 | 0.75 | L3MBTL1 (0.55) | TSHRPOLBNPSR1PSMB5PSMB1 | |
| SCHEMBL12530443 | 0.75 | TSHR (0.51) | TSHRPOLBNPSR1PSMB5PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991009848-A1 | PYRIDINONES USEFUL AS ANTIATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1991-07-11 | — | — | WO | claimed |
| WO-1991009848-A1 | PYRIDINONES USEFUL AS ANTIATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1991-07-11 | — | — | WO | disclosed |