Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.50 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.48 |
| ▸ | PREP | P48147 | 1/20 | 0.48 |
| ▸ | FAP | Q12884 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12530443 | 0.88 | TSHR (0.51) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL1280773 | 0.85 | TSHR (0.56) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL11964126 | 0.83 | TSHR (0.54) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL11827268 | 0.83 | TSHR (0.54) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL4956341 | 0.83 | TSHR (0.54) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL9752613 | 0.81 | TSHR (0.51) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL10656937 | 0.80 | TSHR (0.59) | TSHRPSMB5PSMB1POLBLMNA | |
| SCHEMBL10842925 | 0.79 | TSHR (0.50) | TSHRPSMB5PSMB1PREPFAP | |
| SCHEMBL7095748 | 0.79 | KDM4E (0.53) | TSHRPSMB5PSMB1POLBL3MBTL1 | |
| SCHEMBL20665992 | 0.79 | PSMB5 (0.52) | TSHRPSMB5PSMB1PREPFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991009848-A1 | PYRIDINONES USEFUL AS ANTIATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1991-07-11 | — | — | WO | claimed |
| WO-1991009848-A1 | PYRIDINONES USEFUL AS ANTIATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1991-07-11 | — | — | WO | disclosed |