Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | AKT1 | P31749 | 2/20 | 0.59 |
| ▸ | TDO2 | P48775 | 1/20 | 0.57 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | AHR | P35869 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14571460 | 0.83 | KMT2A (0.80) | MAPTMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL28324629 | 0.81 | ALDH1A1 (0.84) | MAPTMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL2562269 | 0.81 | JUN (0.51) | MAPTALDH1A1TSHRSMN1; SMN2TDO2 | |
| SCHEMBL17643209 | 0.80 | MEN1 (0.80) | MAPTMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL31277320 | 0.80 | KMT2A (0.70) | MAPTMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL17643387 | 0.80 | KMT2A (0.74) | MAPTMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL17643007 | 0.80 | MEN1 (0.70) | MAPTMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL21658322 | 0.80 | KMT2A (0.70) | MAPTMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL17643389 | 0.80 | ESR1 (0.71) | MAPTMEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL4397863 | 0.79 | JUN (0.75) | MAPTMEN1KMT2AHSP90AA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | claimed |
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |