Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.36 |
| ▸ | LIG1 | P18858 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4624362 | 0.78 | MAPT (0.46) | MAPTL3MBTL1HTR2AHTR2CTSHR | |
| SCHEMBL515196 | 0.74 | ADRB2 (0.59) | L3MBTL1TSHRHPGDMAPK1HSD17B10 | |
| SCHEMBL28538422 | 0.74 | HPGD (0.46) | MAPTL3MBTL1HTR2ATSHRHPGD | |
| SCHEMBL8637602 | 0.74 | LIG1 (0.44) | MAPTL3MBTL1HTR2ATSHRHPGD | |
| SCHEMBL28547488 | 0.74 | HPGD (0.43) | MAPTL3MBTL1HTR2ATSHRHPGD | |
| SCHEMBL20454563 | 0.73 | HPGD (0.47) | MAPTL3MBTL1HTR2ATSHRHPGD | |
| SCHEMBL22085950 | 0.73 | ADRB2 (0.44) | MAPTL3MBTL1TSHRHPGDMAPK1 | |
| SCHEMBL5611931 | 0.72 | ADRB2 (0.47) | MAPTL3MBTL1TSHRHPGDMAPK1 | |
| SCHEMBL7764770 | 0.70 | HPGD (0.55) | HTR2ATSHRHPGDMAPK1HSD17B10 | |
| SCHEMBL13685109 | 0.70 | DRD1 (0.50) | L3MBTL1MAPK1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874756-A1 | CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF | Wyeth (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006116165-A1 | CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |