Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 5/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.35 |
| ▸ | SDCBP | O00560 | 1/20 | 0.35 |
| ▸ | SDC2 | P34741 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949144 | 0.94 | PSMB5 (0.39) | POLBPKMATMMEN1KMT2A | |
| SCHEMBL4950026 | 0.90 | KCNJ6 (0.39) | MMP1MMP2MMP9MMP8KCNJ6 | |
| SCHEMBL4958535 | 0.85 | MALT1 (0.39) | MMP1MMP2MMP9MMP8CNR1 | |
| SCHEMBL2965613 | 0.81 | MAPK14 (0.40) | POLBPKMCYP3A4GAACYP2C19 | |
| SCHEMBL8318851 | 0.81 | MAPK14 (0.40) | POLBPKMCYP3A4GAACYP2C19 | |
| SCHEMBL4948937 | 0.81 | PSMB5 (0.37) | POLBPKMPSMB5 | |
| SCHEMBL4939631 | 0.79 | MMP2 (0.46) | MMP1MMP2MMP9MMP8CNR2 | |
| SCHEMBL4949147 | 0.79 | POLB (0.39) | POLBPKMGAAMALT1ATM | |
| SCHEMBL4946819 | 0.77 | PSEN1 (0.44) | — | |
| SCHEMBL4950030 | 0.75 | EP300 (0.37) | MMP1MMP2MMP9MMP8POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633350-A4 | ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS | ELAN PHARM INC (US) | 2008-11-26 | — | — | EP | disclosed |
| EP-1633350-A2 | ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2005009344-A2 | ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS | ELAN PHARMACEUTICALS, INC. (US) | 2005-02-03 | — | — | WO | disclosed |