Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13871292 | 0.87 | FFAR1 (0.34) | EPHX2FFAR1SCN9AALDH1A1KDM4E | |
| SCHEMBL4609693 | 0.83 | PGR (0.37) | SCN9AALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL4103253 | 0.81 | SCN9A (0.37) | SCN9AALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL4114657 | 0.81 | ALDH1A1 (0.36) | FFAR1SCN9AALDH1A1KDM4ELMNA | |
| SCHEMBL4960690 | 0.78 | PGR (0.35) | EPHX2SCN9AALDH1A1KDM4ELMNA | |
| SCHEMBL4099335 | 0.78 | ALDH1A1 (0.35) | SCN9AALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL4105307 | 0.78 | KDM4E (0.34) | SCN9AALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL6001520 | 0.77 | KDM4E (0.32) | SCN9AALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL4105248 | 0.75 | LRRK2 (0.39) | — | |
| SCHEMBL4923554 | 0.74 | TGFBR1 (0.36) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874732-A1 | PYRAZOLE DERIVATIVES AS PROGESTERONE RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006111856-A1 | PYRAZOLE DERIVATIVES AS PROGESTERONE RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 2006-10-26 | — | — | WO | disclosed |