Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 3/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.37 |
| ▸ | AR | P10275 | 4/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4962255 | 0.91 | MRGPRX4 (0.40) | MRGPRX4PGRFFAR4ARNR3C2 | |
| SCHEMBL4112533 | 0.90 | PGR (0.48) | MRGPRX4PGRFFAR4ARNR3C2 | |
| SCHEMBL4959670 | 0.88 | MRGPRX4 (0.39) | MRGPRX4PGRAR | |
| SCHEMBL4960690 | 0.87 | PGR (0.35) | PGRFFAR4MCL1DPP4KCNH2 | |
| SCHEMBL4960107 | 0.86 | AR (0.47) | AR | |
| SCHEMBL4609500 | 0.84 | PGR (0.46) | MRGPRX4PGRAR | |
| SCHEMBL4959617 | 0.83 | PGR (0.50) | PGRFFAR4 | |
| SCHEMBL4114375 | 0.83 | MRGPRX4 (0.36) | MRGPRX4PGRFFAR4ARNR3C2 | |
| SCHEMBL4109845 | 0.81 | PGR (0.44) | MRGPRX4PGRFFAR4ARUSP30 | |
| SCHEMBL4962986 | 0.81 | ATM (0.41) | MRGPRX4PGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874732-A1 | PYRAZOLE DERIVATIVES AS PROGESTERONE RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006111856-A1 | PYRAZOLE DERIVATIVES AS PROGESTERONE RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 2006-10-26 | — | — | WO | disclosed |