Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.53 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964691 | 0.91 | AQP1 (0.43) | AQP1EZH2MTNR1AS1PR2S1PR4 | |
| SCHEMBL4964699 | 0.91 | AQP1 (0.43) | AQP1EZH2MTNR1AS1PR2S1PR4 | |
| SCHEMBL4225278 | 0.90 | AQP1 (0.52) | AQP1EZH2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL13992999 | 0.89 | AQP1 (0.45) | AQP1ALDH1A1HPGDNPC1CYP2C19 | |
| SCHEMBL4596131 | 0.85 | AQP1 (0.71) | AQP1EZH2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL13992998 | 0.84 | AQP1 (0.53) | AQP1EZH2CYP2C19MTNR1AMTNR1B | |
| SCHEMBL4228388 | 0.83 | AQP1 (0.44) | AQP1EZH2ALDH1A1HPGDNPC1 | |
| Hydrochloric Acid SCHEMBL6000525 | 0.83 | PRKAB2 (0.44) | AQP1ALDH1A1HPGDNPC1CYP2C19 | |
| SCHEMBL4230182 | 0.81 | AQP1 (0.42) | AQP1EZH2HPGDS1PR2S1PR4 | |
| SCHEMBL4226305 | 0.81 | CHRM1 (0.44) | AQP1EZH2ALDH1A1NPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470799-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470799-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470799-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1871754-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116136-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |
| US-20060246551-A1 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2006-11-02 | — | — | US | disclosed |