Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 6/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964691 | 1.00 | AQP1 (0.43) | AQP1S1PR4CHRM1CHRM3MTNR1A | |
| SCHEMBL4959672 | 0.91 | AQP1 (0.53) | AQP1S1PR4MTNR1AS1PR2S1PR3 | |
| SCHEMBL4230182 | 0.90 | AQP1 (0.42) | AQP1S1PR4CHRM1CHRM3S1PR2 | |
| SCHEMBL13992999 | 0.89 | AQP1 (0.45) | AQP1MTNR1ARORCMTNR1BPRKAB2 | |
| SCHEMBL4596919 | 0.85 | AQP1 (0.58) | AQP1S1PR4CHRM1CHRM3S1PR2 | |
| SCHEMBL13992998 | 0.84 | AQP1 (0.53) | AQP1MTNR1ARORCMTNR1BEZH2 | |
| SCHEMBL4962532 | 0.83 | AQP1 (0.47) | AQP1S1PR4MTNR1ARORCMTNR1B | |
| SCHEMBL4226305 | 0.83 | CHRM1 (0.44) | AQP1S1PR4CHRM1S1PR2S1PR3 | |
| Hydrochloric Acid SCHEMBL6000525 | 0.83 | PRKAB2 (0.44) | AQP1MTNR1AMTNR1BPRKAB2PRKAG1 | |
| SCHEMBL4225278 | 0.81 | AQP1 (0.52) | AQP1S1PR4CHRM1S1PR2S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470799-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1871754-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116136-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |
| US-20060246551-A1 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2006-11-02 | — | — | US | disclosed |