Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.42 |
| ▸ | AQP1 | P29972 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | CALML3 | P27482 | 1/20 | 0.36 |
| ▸ | SDHA | P31040 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 3/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4230959 | 0.92 | AQP1 (0.39) | MTNR1AAQP1ALDH1A1MAPK1LMNA | |
| SCHEMBL4960669 | 0.90 | AQP1 (0.47) | MTNR1AAQP1MTNR1BALDH1A1MAOA | |
| SCHEMBL13993001 | 0.86 | MTNR1A (0.43) | MTNR1AAQP1MTNR1BMAOAMAOB | |
| SCHEMBL4230830 | 0.85 | AQP1 (0.52) | AQP1ALDH1A1MAPK1PRKAB2PRKAG1 | |
| SCHEMBL4963338 | 0.82 | AQP1 (0.50) | MTNR1AAQP1MTNR1BALDH1A1MAPK1 | |
| SCHEMBL4963332 | 0.82 | AQP1 (0.50) | MTNR1AAQP1MTNR1BALDH1A1MAPK1 | |
| SCHEMBL4226843 | 0.82 | PRKAB2 (0.39) | AQP1ALDH1A1MAPK1PRKAB2PRKAG1 | |
| SCHEMBL4220483 | 0.80 | PRKAB2 (0.50) | AQP1ALDH1A1MAPK1PRKAB2PRKAG1 | |
| SCHEMBL4230833 | 0.79 | PRKAB2 (0.41) | AQP1ALDH1A1MAPK1PRKAB2PRKAG1 | |
| SCHEMBL4961605 | 0.78 | AQP1 (0.58) | MTNR1AAQP1MTNR1BMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470799-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470799-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470799-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1871754-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116136-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |
| US-20060246551-A1 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2006-11-02 | — | — | US | disclosed |