Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | FADS1 | O60427 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31636847 | 0.76 | ENPP3 (0.46) | ADORA2AMAPTADORA1ADORA2BGSK3B | |
| SCHEMBL31636670 | 0.71 | KDM4E (0.44) | ADORA2AGAAMAPTADORA1ADORA2B | |
| SCHEMBL6384067 | 0.70 | EGFR (0.58) | EGFRERBB2TDO2IDO1SRC | |
| SCHEMBL4960986 | 0.69 | EGFR (0.54) | EGFRERBB2SRC | |
| SCHEMBL4962384 | 0.68 | KDM1A (0.42) | ADORA2AMAPTADORA1IDO1ALDH1A1 | |
| SCHEMBL30950214 | 0.65 | ENPP1 (0.48) | ADORA2AGAAMAPTADORA1ADORA2B | |
| SCHEMBL28676590 | 0.65 | ENPP1 (0.48) | ADORA2AGAAMAPTADORA1ADORA2B | |
| SCHEMBL8116143 | 0.64 | GAA (0.62) | EGFRGAAMAPTFADS1ROCK1 | |
| SCHEMBL8116583 | 0.64 | TSHR (0.54) | EGFRERBB2ADORA2AGAAMAPT | |
| SCHEMBL6222695 | 0.64 | NPC1 (0.60) | EGFRERBB2GAAMAPTHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888529-A2 | 3-CYANOQUINOLINE INHIBITORS OF TPL2 KINASE AND METHODS OF MAKING AND USING THE SAME | Wyeth (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006124692-A2 | 3-CYANOQUINOLINE INHIBITORS OF TPL2 KINASE AND METHODS OF MAKING AND USING THE SAME | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |