Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 1/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30950214 | 0.84 | ENPP1 (0.48) | ENPP3ENPP1ALDH1A1ADORA2AADORA1 | |
| SCHEMBL28676590 | 0.84 | ENPP1 (0.48) | ENPP3ENPP1ALDH1A1ADORA2AADORA1 | |
| SCHEMBL31636670 | 0.82 | KDM4E (0.44) | ALDH1A1ADORA2AADORA1KDM4ESMN1; SMN2 | |
| SCHEMBL25295905 | 0.79 | KDM4E (0.38) | ALDH1A1ADORA2AADORA1KDM4ERXFP1 | |
| SCHEMBL4960499 | 0.76 | EGFR (0.39) | ALDH1A1ADORA2AADORA1MAPTKMT2A | |
| SCHEMBL3521028 | 0.74 | KDM4E (0.56) | ALDH1A1ADORA2AADORA1KDM4ESMN1; SMN2 | |
| SCHEMBL31636611 | 0.74 | KDM4E (0.56) | ALDH1A1ADORA2AADORA1KDM4ESMN1; SMN2 | |
| SCHEMBL8442820 | 0.74 | ENPP1 (0.61) | ENPP3ENPP1ALDH1A1ADORA1SMN1; SMN2 | |
| SCHEMBL9794609 | 0.72 | KDM4E (0.39) | ALDH1A1ADORA2AADORA1KDM4EMEN1 | |
| SCHEMBL558306 | 0.70 | HTT (0.46) | ENPP3ENPP1ALDH1A1ADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025137158-A1 | DERIVATIVES OF ([1,2,4]TRIAZOLO[5,1-A]ISOQUINOLINE-5-CARBONYL)GLYCINATE AS PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2025-06-26 | — | — | WO | disclosed |