Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.77 |
| ▸ | POLB | P06746 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972667 | 0.87 | MEN1 (0.62) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL31054249 | 0.87 | NPC1 (1.00) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL651929 | 0.87 | NPC1 (1.00) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL30741445 | 0.85 | NPC1 (0.79) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL4890353 | 0.85 | NPC1 (0.79) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL28359062 | 0.85 | ALDH1A1 (0.72) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL4526983 | 0.84 | NPC1 (0.67) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL10310270 | 0.84 | NPC1 (0.67) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL29944526 | 0.84 | NPC1 (0.77) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL18885828 | 0.84 | NPC1 (0.77) | NPC1POLBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630373-A1 | INDOLE DERIVATIVES AS 5HT1C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-28 | — | — | EP | claimed |
| CN-108658869-A | Compound with anti-tumor activity and preparation method thereof and the purposes in pharmacy | 复旦大学 | 2018-10-16 | — | — | CN | disclosed |
| EP-1969051-A2 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | N.V. Organon (NL) | 2008-09-17 | — | — | EP | disclosed |
| WO-2008024139-A2 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | N.V. ORGANON (NL) | 2008-02-28 | — | — | WO | disclosed |
| WO-2007079180-A2 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | N.V. ORGANON (NL) | 2007-07-12 | — | — | WO | disclosed |