Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14949475 | 0.89 | DGAT1 (0.42) | GAACA1CA2CA12TDP1 | |
| SCHEMBL151345 | 0.79 | GAA (0.44) | GAACA1CA2CA12CA9 | |
| SCHEMBL101218 | 0.78 | DGAT1 (0.46) | GAACA1CA2CA12TDP1 | |
| SCHEMBL9923753 | 0.77 | GAA (0.40) | GAACA1CA2CA12CA9 | |
| SCHEMBL12246341 | 0.77 | CA1 (0.39) | GAACA1CA2CA12TDP1 | |
| SCHEMBL6272856 | 0.76 | DGAT1 (0.44) | GAACA1CA2CA12TDP1 | |
| SCHEMBL1522412 | 0.76 | DGAT1 (0.44) | GAACA1CA2CA12TDP1 | |
| Potassium SCHEMBL29554503 | 0.76 | DGAT1 (0.44) | GAACA1CA2CA12TDP1 | |
| SCHEMBL1616863 | 0.76 | TAS2R38 (0.46) | GAACA1CA2CA12CA9 | |
| SCHEMBL7339169 | 0.76 | GAA (0.39) | GAACA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |