Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL151345 | 0.81 | GAA (0.44) | GAACA1CA2CA12CA9 | |
| SCHEMBL101218 | 0.80 | DGAT1 (0.46) | GAACA1CA2CA12TDP1 | |
| SCHEMBL9923753 | 0.79 | GAA (0.40) | GAACA1CA2CA12CA9 | |
| SCHEMBL6272856 | 0.78 | DGAT1 (0.44) | GAACA1CA2CA12TDP1 | |
| SCHEMBL1522412 | 0.78 | DGAT1 (0.44) | GAACA1CA2CA12TDP1 | |
| Potassium SCHEMBL29554503 | 0.78 | DGAT1 (0.44) | GAACA1CA2CA12TDP1 | |
| SCHEMBL1616863 | 0.77 | TAS2R38 (0.46) | GAACA1CA2CA12CA9 | |
| SCHEMBL604019 | 0.76 | TDP1 (0.39) | GAACA1CA2CA12TDP1 | |
| SCHEMBL4960633 | 0.76 | GAA (0.38) | GAACA1CA2CA12CA9 | |
| SCHEMBL2720 | 0.76 | GAA (0.41) | GAACA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6077854-A | Tri-substituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-06-20 | — | — | US | disclosed |
| EP-0944599-A1 | TRIARYLETHANES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-29 | — | — | EP | disclosed |
| US-5891896-A | Tri-substituted phenyl derivatives useful as PDE IV inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1999-04-06 | — | — | US | disclosed |
| US-5859034-A | Tri-substituted phenyl compounds which have useful pharmaceutical activity | CELLTECH THERAPEUTICS, LIMITED (GB) | 1999-01-12 | — | — | US | disclosed |
| US-5849770-A | Tri-substituted phenyl derivatives useful as PDE IV inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1998-12-15 | — | — | US | disclosed |
| EP-0874823-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-11-04 | — | — | EP | disclosed |
| EP-0874824-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-11-04 | — | — | EP | disclosed |
| US-5798373-A | Tri-substituted phenyl derivatives useful as PDE IV inhibitors | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-08-25 | — | — | US | disclosed |
| US-5786354-A | Tri-substituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-07-28 | — | — | US | disclosed |
| WO-1998028276-A1 | TRIARYLETHANES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-07-02 | — | — | WO | disclosed |
| WO-1997023460-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-07-03 | — | — | WO | disclosed |
| WO-1997023461-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-07-03 | — | — | WO | disclosed |
| EP-0770065-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-02 | — | — | EP | disclosed |
| WO-1995035281-A1 | TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |