Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576103 | 0.85 | KDM4E (0.74) | LMNAKDM4EGAAPOLBKMT2A | |
| SCHEMBL15873902 | 0.84 | KDM4E (0.73) | LMNAKDM4EGAAPOLBCYP1A2 | |
| SCHEMBL7011229 | 0.84 | LMNA (0.72) | LMNAKDM4EGAAPOLB | |
| SCHEMBL6917461 | 0.82 | KDM4E (0.69) | LMNAKDM4EGAAPOLB | |
| SCHEMBL29191107 | 0.81 | KDM4E (0.68) | LMNAKDM4EGAAPOLB | |
| SCHEMBL16740571 | 0.81 | KDM4E (0.72) | LMNAKDM4EGAAPOLB | |
| SCHEMBL3339441 | 0.81 | KDM4E (0.72) | LMNAKDM4EGAAKMT2AL3MBTL1 | |
| SCHEMBL28928823 | 0.79 | LMNA (0.65) | LMNAKDM4EPOLBKMT2AL3MBTL1 | |
| SCHEMBL15873819 | 0.77 | KDM4E (0.63) | LMNAKDM4EGAAPOLBKMT2A | |
| SCHEMBL28928872 | 0.77 | LMNA (0.62) | LMNAKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896454-A1 | AMlNO-5-(5-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR -SECRETASE MODULATION | Wyeth a Corporation of the State of Delaware (US) | 2008-03-12 | — | — | EP | claimed |
| WO-2007005366-A1 | AMlNO-5-(5-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-01-11 | — | — | WO | claimed |