Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576103 | 0.83 | KDM4E (0.74) | KDM4ELMNAHDAC6HDAC8HDAC2 | |
| SCHEMBL4961237 | 0.82 | LMNA (1.00) | KDM4ELMNAGAAPOLB | |
| SCHEMBL15873902 | 0.82 | KDM4E (0.73) | KDM4ELMNAHDAC6HDAC1HDAC8 | |
| SCHEMBL2414816 | 0.79 | HDAC2 (0.66) | KDM4EHDAC6HDAC1HDAC8HDAC2 | |
| SCHEMBL3339441 | 0.78 | KDM4E (0.72) | KDM4ELMNAGAA | |
| SCHEMBL16740571 | 0.78 | KDM4E (0.72) | KDM4ELMNAHDAC6HDAC1HDAC8 | |
| SCHEMBL29191107 | 0.78 | KDM4E (0.68) | KDM4ELMNAHDAC6HDAC1HDAC8 | |
| SCHEMBL447806 | 0.78 | NPC1 (0.55) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL2829167 | 0.78 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL5204640 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106632-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |