Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966191 | 0.89 | GAK (0.49) | GAKFPR2SCN9ACDK9KDM4E | |
| SCHEMBL613561 | 0.82 | NPC1 (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL15911942 | 0.80 | CDK9 (0.47) | CDK9PBKEIF2AK4KDM4EABL1 | |
| SCHEMBL13658037 | 0.77 | KDM4E (0.56) | CDK9PBKEIF2AK4KDM4EABL1 | |
| SCHEMBL13662096 | 0.77 | CDK9 (0.50) | CDK9PBKEIF2AK4KDM4EABL1 | |
| SCHEMBL27991057 | 0.74 | KDM4E (0.73) | SCN9AEIF2AK4KDM4EABL1LMNA | |
| SCHEMBL5430879 | 0.72 | DGAT2 (0.49) | CDK9PBKEIF2AK4KDM4EABL1 | |
| SCHEMBL23582992 | 0.72 | KMT2A (0.56) | KDM4EABL1LMNAKMT2A | |
| SCHEMBL27856595 | 0.72 | CDK9 (0.52) | GAKFPR2SCN9ACDK9EIF2AK4 | |
| SCHEMBL27873347 | 0.72 | CDK9 (0.52) | GAKFPR2SCN9ACDK9EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758580-A4 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-16 | — | — | EP | claimed |
| EP-1758580-A2 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2006012226-A2 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | claimed |