Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4961975 | 0.89 | PIK3CD (0.51) | GAKFPR2SCN9ADGAT2CDK9 | |
| SCHEMBL27665014 | 0.82 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2ALDH1A1DGAT2 | |
| SCHEMBL613084 | 0.82 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2ALDH1A1DGAT2 | |
| SCHEMBL15911942 | 0.80 | CDK9 (0.47) | ALDH1A1CDK9KDM4EHPGDKMT2A | |
| SCHEMBL2446468 | 0.80 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL29086063 | 0.77 | HRH3 (0.46) | RAB9ANPC1SMN1; SMN2POLBKDM4E | |
| Hydrochloric Acid SCHEMBL30585985 | 0.77 | HRH3 (0.46) | RAB9ANPC1SMN1; SMN2POLBKDM4E | |
| SCHEMBL13658037 | 0.77 | KDM4E (0.56) | ALDH1A1DGAT2POLBCDK9KDM4E | |
| SCHEMBL13662096 | 0.77 | CDK9 (0.50) | RAB9ANPC1SMN1; SMN2ALDH1A1CDK9 | |
| SCHEMBL5239769 | 0.76 | EGLN1 (0.49) | RAB9ANPC1SMN1; SMN2EGLN1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758580-A4 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-16 | — | — | EP | claimed |
| EP-1758580-A2 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2006012226-A2 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | claimed |