SCHEMBL4962222

SCHEMBL4962222

O=C([O-])C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F.c1ccc([S+](c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.42
CA1 P00915 13/20 0.38
CA2 P00918 13/20 0.38
HDAC1 Q13547 4/20 0.37
HDAC7 Q8WUI4 4/20 0.37
HDAC8 Q9BY41 4/20 0.37
HDAC6 Q9UBN7 4/20 0.37
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
CES1 P23141 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4962460 1.00 THRB (0.42) THRBCA1CA2HDAC1HDAC7
SCHEMBL4962900 1.00 THRB (0.42) THRBCA1CA2HDAC1HDAC7
SCHEMBL4962404 1.00 THRB (0.42) THRBCA1CA2HDAC1HDAC7
SCHEMBL29746113 0.98 THRB (0.39) THRBCA1CA2HDAC1HDAC7
SCHEMBL1573975 0.98 THRB (0.39) THRBCA1CA2HDAC1HDAC7
SCHEMBL4962904 0.95 HDAC1 (0.40) THRBCA1CA2HDAC1HDAC7
SCHEMBL29745841 0.93 CES1 (0.34) THRBCA1CA2HDAC1HDAC7
SCHEMBL545780 0.93 CES1 (0.34) THRBCA1CA2HDAC1HDAC7
SCHEMBL4964156 0.91 GAA (0.41) THRBCA1CA2HDAC1HDAC7
SCHEMBL4961195 0.91 GAA (0.41) THRBCA1CA2HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1314725-B1 SULFONIUM SALT COMPOUND WAKO PURE CHEM IND LTD (JP) 2008-03-19 EP claimed
EP-1314725-B1 SULFONIUM SALT COMPOUND WAKO PURE CHEM IND LTD (JP) 2008-03-19 EP disclosed