Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.47 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.42 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 4/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4959742 | 0.90 | AQP1 (0.44) | AQP1EZH2MTNR1ACYP3A4CYP2C19 | |
| SCHEMBL4961651 | 0.89 | AQP1 (0.59) | AQP1EZH2MTNR1ACYP3A4CYP2C19 | |
| SCHEMBL4960925 | 0.88 | AQP1 (0.43) | AQP1EZH2MTNR1ACYP3A4CYP2C19 | |
| SCHEMBL13992999 | 0.87 | AQP1 (0.45) | AQP1MTNR1ACYP3A4CYP2C19RECQL | |
| SCHEMBL4960669 | 0.86 | AQP1 (0.47) | AQP1EZH2MTNR1ACYP3A4CYP2C19 | |
| SCHEMBL4964699 | 0.83 | AQP1 (0.43) | AQP1EZH2MTNR1ARORCMTNR1B | |
| SCHEMBL4964691 | 0.83 | AQP1 (0.43) | AQP1EZH2MTNR1ARORCMTNR1B | |
| SCHEMBL4236357 | 0.83 | EZH2 (0.44) | AQP1EZH2USP7RAB9ANPC1 | |
| SCHEMBL13992998 | 0.83 | AQP1 (0.53) | AQP1EZH2MTNR1ACYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL6000525 | 0.82 | PRKAB2 (0.44) | AQP1MTNR1ACYP3A4CYP2C19RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470799-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470799-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470799-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1871754-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116136-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |
| US-20060246551-A1 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2006-11-02 | — | — | US | disclosed |