SCHEMBL4963010

SCHEMBL4963010

O=P(O)(O)S(=O)(=O)COc1cc(Br)c(Oc2ccc(O)c(Cc3ccc(F)cc3)c2)c(Br)c1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRA P10827 16/20 0.48
THRB P10828 16/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3156760 0.86 THRA (0.59) THRATHRB
SCHEMBL13382173 0.84 THRA (0.52) THRATHRB
SCHEMBL13703153 0.83 THRA (0.51) THRATHRB
SCHEMBL13382158 0.82 THRA (0.50) THRATHRB
SCHEMBL13381767 0.80 THRA (0.48) THRATHRB
SCHEMBL3160749 0.80 THRB (0.57) THRATHRB
SCHEMBL4201465 0.79 THRA (0.52) THRATHRB
SCHEMBL4205797 0.78 THRA (0.51) THRATHRB
SCHEMBL4965529 0.78 THRB (0.56) THRATHRB
SCHEMBL13946877 0.75 THRA (0.52) THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1890768-A2 NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS Metabasis Therapeutics, Inc. (US) 2008-02-27 EP disclosed
WO-2006128056-A2 NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS METABASIS THERAPEUTICS, INC. (US) 2006-11-30 WO disclosed