Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 15/20 | 0.56 |
| ▸ | THRA | P10827 | 14/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL281956 | 0.85 | THRB (0.77) | THRBTHRA | |
| SCHEMBL4963877 | 0.83 | THRB (0.64) | THRBTHRA | |
| SCHEMBL13381679 | 0.81 | THRB (0.60) | THRBTHRA | |
| SCHEMBL1458123 | 0.81 | THRB (0.54) | THRBTHRA | |
| SCHEMBL23003762 | 0.80 | THRB (0.66) | THRBTHRA | |
| SCHEMBL25528700 | 0.80 | THRB (0.53) | THRBTHRA | |
| SCHEMBL282417 | 0.78 | THRB (0.54) | THRBTHRA | |
| SCHEMBL4963010 | 0.78 | THRA (0.48) | THRBTHRA | |
| SCHEMBL3153210 | 0.77 | THRA (0.62) | THRBTHRA | |
| SCHEMBL4215935 | 0.77 | THRA (0.49) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890768-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128056-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |