Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.46 |
| ▸ | HTR3A | P46098 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5360932 | 0.71 | HTR6 (0.55) | HTR6HSD17B10ALDH1A1CASP1CASP7 | |
| Hydrochloric Acid SCHEMBL5429686 | 0.70 | HTR6 (0.54) | HTR6HSD17B10ALDH1A1CASP1CASP7 | |
| SCHEMBL5360129 | 0.69 | HTR6 (0.51) | HTR6HTR2CALDH1A1HTR1ASIGMAR1 | |
| SCHEMBL4615627 | 0.68 | HTR6 (0.54) | HTR6HTR2CHTR1ASLC6A2SLC6A4 | |
| SCHEMBL4967183 | 0.68 | HTR2C (0.46) | HTR6HTR3AHTR2CHSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4615155 | 0.67 | HTR6 (0.53) | HTR6HTR2CALDH1A1HPGDHTR1A | |
| SCHEMBL3857908 | 0.66 | HTR6 (0.65) | HTR6HTR2CALDH1A1HTR1ASLC6A2 | |
| SCHEMBL24323848 | 0.66 | GAA (0.82) | ALDH1A1SMN1; SMN2MAPK1GAAHTT | |
| SCHEMBL41969 | 0.66 | SIGMAR1 (0.79) | HTR1ASLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL3963041 | 0.66 | SIGMAR1 (0.79) | HTR1ASLC6A4SLC6A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904483-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | claimed |
| WO-2007006677-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | claimed |