Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 5/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966480 | 0.91 | TAAR1 (0.46) | HTR2CHTR6HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4963734 | 0.77 | ADRB1 (0.38) | HTR6HTR1AALDH1A1CYP2C19SMN1; SMN2 | |
| SCHEMBL4963389 | 0.68 | HTR6 (0.46) | HTR2CHTR6HTR1ASLC6A2SLC6A4 | |
| SCHEMBL16653731 | 0.64 | TAAR1 (0.77) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| Piperazine SCHEMBL1764131 | 0.62 | SIGMAR1 (0.55) | HTR2CSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL28340861 | 0.62 | HTR6 (0.47) | HTR2CHTR6HTR1ASLC6A2SLC6A4 | |
| SCHEMBL8457378 | 0.62 | ADRB1 (0.60) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11064918 | 0.62 | AOC3 (0.64) | HTR2CALDH1A1CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL3266417 | 0.61 | AOC3 (0.65) | HTR2CHTR6HTR1ASLC6A4ALDH1A1 | |
| SCHEMBL15834279 | 0.60 | ADRB1 (0.75) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904483-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | claimed |
| WO-2007006677-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | claimed |