Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 12/20 | 0.66 |
| ▸ | THRB | P10828 | 12/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL283169 | 0.92 | THRA (0.69) | THRATHRBESR1ESR2BACE1 | |
| SCHEMBL281929 | 0.85 | THRA (0.63) | THRATHRB | |
| SCHEMBL13381677 | 0.85 | THRA (0.61) | THRATHRBESR1ESR2BACE1 | |
| SCHEMBL3153210 | 0.84 | THRA (0.62) | THRATHRBESR1ESR2CNR2 | |
| SCHEMBL4964401 | 0.82 | THRA (0.48) | THRATHRBALOX5ESR1ESR2 | |
| SCHEMBL13946904 | 0.82 | THRA (0.58) | THRATHRBESR1ESR2BACE1 | |
| SCHEMBL283584 | 0.80 | THRB (0.82) | THRATHRBESR1ESR2 | |
| SCHEMBL282249 | 0.80 | THRB (1.00) | THRATHRB | |
| SCHEMBL21291330 | 0.78 | THRA (0.64) | THRATHRBESR1ESR2GRIN2D | |
| SCHEMBL4962366 | 0.78 | THRB (0.69) | THRATHRBALOX5BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890768-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128056-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |