Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 11/20 | 0.48 |
| ▸ | THRB | P10828 | 11/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | SHBG | P04278 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963440 | 0.82 | THRA (0.66) | THRATHRBESR1ESR2ALOX5 | |
| SCHEMBL5372926 | 0.82 | ALOX5 (0.57) | ESR1ESR2ALOX5CNR1CNR2 | |
| SCHEMBL68146 | 0.81 | ALOX5 (0.59) | ESR1ESR2ALOX5CNR1CNR2 | |
| SCHEMBL20601960 | 0.78 | THRB (0.67) | THRATHRBALOX5 | |
| SCHEMBL1021086 | 0.75 | ALOX5 (0.71) | ALOX5CNR1CNR2BACE1LMNA | |
| SCHEMBL1457668 | 0.75 | THRB (0.67) | THRATHRBESR1ESR2 | |
| SCHEMBL27761299 | 0.74 | ALOX5 (0.60) | ALOX5CNR1CNR2BACE1LMNA | |
| SCHEMBL9339864 | 0.74 | HTT (0.47) | THRATHRBESR1ESR2ALOX5 | |
| SCHEMBL1021610 | 0.73 | TRPA1 (0.59) | ESR1ESR2ALOX5CNR1CNR2 | |
| SCHEMBL4962366 | 0.73 | THRB (0.69) | THRATHRBALOX5BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890768-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128056-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |