Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.43 |
| ▸ | ROS1 | P08922 | 4/20 | 0.43 |
| ▸ | FLT3 | P36888 | 4/20 | 0.43 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963132 | 0.86 | L3MBTL1 (0.49) | ALDH1A1CYP3A4LMNASMN1; SMN2 | |
| SCHEMBL4963137 | 0.86 | L3MBTL1 (0.49) | ALDH1A1CYP3A4LMNASMN1; SMN2 | |
| SCHEMBL4964821 | 0.84 | MAPT (0.51) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4964826 | 0.84 | MAPT (0.51) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4964872 | 0.77 | HDAC4 (0.51) | NPC1RAB9ALMNA | |
| SCHEMBL31430188 | 0.76 | FPR2 (0.58) | ALDH1A1 | |
| SCHEMBL4964952 | 0.71 | PDK2 (0.45) | ALKALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL4964877 | 0.71 | PDK2 (0.45) | ALKALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL25975350 | 0.68 | OPRM1 (0.44) | ALDH1A1 | |
| SCHEMBL22816718 | 0.68 | ESR2 (0.50) | ALDH1A1CYP3A4HDAC3HDAC8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773780-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-09 | — | — | EP | claimed |
| EP-1773780-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006012227-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | claimed |