Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4962936 | 0.99 | HTR6 (0.43) | HTR6SLC6A2SLC6A3SLC6A4HTR1A | |
| SCHEMBL4967691 | 0.94 | HTR6 (0.39) | HTR6SLC6A2SLC6A3SLC6A4HTR1A | |
| SCHEMBL4965972 | 0.82 | HTR6 (0.44) | HTR6SLC6A2SLC6A3SLC6A4HTR1A | |
| SCHEMBL4977286 | 0.76 | HTR6 (0.38) | HTR6SLC6A2SLC6A3SLC6A4HTR1A | |
| SCHEMBL152514 | 0.73 | HTR2C (0.45) | HTR6SLC6A2SLC6A3SLC6A4HTR1A | |
| SCHEMBL4962966 | 0.72 | DRD2 (0.48) | — | |
| SCHEMBL3854328 | 0.67 | KMT2A (0.47) | HTR6SLC6A2SLC6A3SLC6A4HTR1A | |
| Hydrochloric Acid SCHEMBL3856321 | 0.67 | KMT2A (0.47) | HTR6SLC6A2SLC6A3SLC6A4HTR1A | |
| SCHEMBL14597077 | 0.65 | HTR6 (0.46) | HTR6SLC6A2SLC6A3SLC6A4HTR1A | |
| SCHEMBL17974655 | 0.64 | PDK2 (0.44) | HTR1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904483-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | claimed |
| WO-2007006677-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | claimed |
| EP-1904483-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006677-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | disclosed |