Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965972 | 0.94 | HTR6 (0.44) | HTR6HTR2CHTR2BSLC6A2SLC6A3 | |
| SCHEMBL4966050 | 0.88 | GABRA1 (0.38) | SLC6A2SLC6A3SLC6A4HTR1AHRH1 | |
| Hydrochloric Acid SCHEMBL4966442 | 0.87 | GABRA1 (0.38) | SLC6A2SLC6A3SLC6A4HTR1AHRH1 | |
| SCHEMBL4977909 | 0.84 | CXCR2 (0.34) | SLC6A2SLC6A3SLC6A4HTR1AMPO | |
| SCHEMBL4967691 | 0.82 | HTR6 (0.39) | HTR6HTR2CHTR2BHTR2ASLC6A2 | |
| SCHEMBL4964175 | 0.76 | HTR6 (0.44) | HTR6HTR2CHTR2BSLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL4962936 | 0.75 | HTR6 (0.43) | HTR6HTR2CHTR2BSLC6A2SLC6A3 | |
| SCHEMBL4965409 | 0.72 | GABRA1 (0.40) | HTR2CHTR2BHTR2ASLC6A2SLC6A3 | |
| SCHEMBL4964731 | 0.69 | KIT (0.42) | SLC6A2SLC6A3SLC6A4HRH1 | |
| SCHEMBL4964772 | 0.68 | HRH1 (0.51) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904483-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | claimed |
| WO-2007006677-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | claimed |