Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 4/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15679953 | 0.82 | ATM (0.50) | EPHX1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL879436 | 0.82 | EPHX1 (0.54) | EPHX1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL268852 | 0.82 | ATM (0.50) | EPHX1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL19820046 | 0.82 | EPHX1 (0.48) | EPHX1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL24213834 | 0.80 | ATM (0.53) | EPHX1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL22679468 | 0.80 | EPHX1 (0.52) | EPHX1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL22546666 | 0.80 | ATM (0.53) | EPHX1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL24213833 | 0.80 | ATM (0.53) | EPHX1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL22546809 | 0.80 | ATM (0.53) | EPHX1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL22546765 | 0.80 | ATM (0.53) | EPHX1SMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470815-B1 | Selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2008-12-30 | — | — | US | disclosed |
| US-20050159363-A1 | Selective neuronal nitric oxide synthase inhibitors | SILVERMAN RICHARD B (US) | 2005-07-21 | — | — | US | disclosed |
| US-6803486-B2 | PEPTIDOMIMETIC; N-AMINOBUTYL-N'-NITROGUANIDINE DERIVATIVES | NORTHWESTERN UNIVERSITY | 2004-10-12 | — | — | US | disclosed |
| US-20030119751-A1 | Selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY | 2003-06-26 | — | — | US | disclosed |
| WO-2003000198-A2 | SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS | NORTHWESTERN UNIVERSITY (US) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159363-A1 | Selective neuronal nitric oxide synthase inhibitors | NOS1, NOS3, NOS2 | EPHX1 849/4885SMN1; SMN2 319/4885NPC1 2015/4885 |
| US-20030119751-A1 | Selective neuronal nitric oxide synthase inhibitors | NOS1, NOS3, NOS2 | EPHX1 849/4885SMN1; SMN2 319/4885NPC1 2015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.