Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241534 | 0.84 | MAPT (0.48) | MAPTCYP1A2CYP2C19CYP2C9HTT | |
| SCHEMBL8241703 | 0.82 | MAPT (0.48) | MAPTCYP1A2CYP2C19CYP2C9HTT | |
| SCHEMBL17896593 | 0.78 | MAPT (0.56) | MAPTCYP1A2CYP2C19CYP2C9HTT | |
| SCHEMBL29525723 | 0.78 | MAPT (0.56) | MAPTCYP1A2CYP2C19CYP2C9HTT | |
| Bromide SCHEMBL11023029 | 0.77 | HCAR3 (0.52) | MAPTCYP1A2CYP2C19CYP2C9HTT | |
| SCHEMBL28737547 | 0.77 | MAPT (0.55) | MAPTCYP1A2CYP2C19CYP2C9HTT | |
| SCHEMBL14413848 | 0.76 | MAPT (0.40) | MAPTCYP1A2CYP2C19CYP2C9HTT | |
| SCHEMBL4965097 | 0.76 | BRD4 (0.41) | CYP1A2CYP2C19CYP2C9MEN1KMT2A | |
| SCHEMBL20338334 | 0.76 | MEN1 (0.58) | MAPTCYP1A2CYP2C19CYP2C9HTT | |
| SCHEMBL13689794 | 0.75 | MAPT (0.41) | MAPTCYP1A2CYP2C19CYP2C9HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934199-A2 | INDANE DERIVATIVES AS MCH RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007039462-A2 | INDANE DERIVATIVES AS MCH RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-12 | — | — | WO | disclosed |