Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | NAMPT | P43490 | 1/20 | 0.64 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.64 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897778 | 0.88 | TSHR (0.65) | TSHRRAB9ANPC1L3MBTL1CYP11B1 | |
| SCHEMBL403822 | 0.87 | TSHR (0.67) | TSHRRAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL11090153 | 0.84 | NAMPT (0.78) | RAB9ANPC1L3MBTL1NAMPTCYP11B1 | |
| SCHEMBL398150 | 0.84 | TSHR (0.66) | TSHRRAB9ANPC1L3MBTL1NAMPT | |
| SCHEMBL27903120 | 0.83 | RAB9A (1.00) | TSHRRAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL403003 | 0.82 | KCNQ3 (0.68) | RAB9AMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL15683903 | 0.81 | TSHR (0.57) | TSHRRAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL15683400 | 0.80 | ALDH1A1 (0.56) | TSHRRAB9ANPC1L3MBTL1MEN1 | |
| SCHEMBL3790049 | 0.80 | MAPT (0.83) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL14426548 | 0.80 | RAB9A (0.78) | TSHRRAB9ANPC1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |